Its somewhat complex. Protein structures are usually solved with x-ray crystallography. You get a 2-dimensional diffraction pattern. There are different methods to “solve” the diffraction pattern and get the Protein structure. Most are a lot of work, including biochemical lab work. But if you have a model it is relatively easy. The modern computer generated models have revolutionized protein x-ray crystallography.
A reliable way to simulate any kind of protein fold. As long as you have a method you could hypothetically “solve” the issue
You dont solve anything. You generate models. That’s it. Without experimental validation they are just cartoons.
Then why has modelling been so focused on?
Because the models become a database you can search for certain characteristics.
(This is a guess I consider reasonable.)
Its somewhat complex. Protein structures are usually solved with x-ray crystallography. You get a 2-dimensional diffraction pattern. There are different methods to “solve” the diffraction pattern and get the Protein structure. Most are a lot of work, including biochemical lab work. But if you have a model it is relatively easy. The modern computer generated models have revolutionized protein x-ray crystallography.