I believe Pangolin is also using Wireguard. Pangolin is basically a self hosted Tailscale. I think the biggest advantage is the ease of management, but I’ve never used Pangolin or Tailscale so I couldn’t really tell you.

I have wireguard on my router. To me it makes sense. If my router is down, nothing inside my network is reachable anyway. If I’m going through my router, anything inside my network can be rebooted without effecting my connection. That said, I’m really considering using Pangolin https://github.com/fosrl/pangolin, and hosting it in Oracle Cloud. If you don’t know, Oracle Cloud has an extremely generous free tier. As much as I generally hate Oracle, I still recommend their free tier.