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Cake day: July 3rd, 2023

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  • Ethics are a big hurdle, but I wouldn’t call it the biggest. Mengele was a conscienceless monster who played at pseudo science.

    The biggest hurdle to gene editing is that it’s fucking hard. Even Mengele V2.0 with no morals and a stable of daily test subjects wouldn’t lead to a ‘mastery’ that lets you merely select for your changes to only include digesting lignin and cellulose.

    Seriously. It’s really hard to even model within acceptable error margins, what the results of gene therapy will be. The potential for disastrous results also only goes up the more complex the interactions you’re trying to affect.

    At current time, even some of the best recorded attempts which are decidedly positively quality of life altering (e.g. [emphasis mine] https://www.science.org/content/article/gene-editing-therapy-made-just-6-months-helps-baby-life-threatening-disease) still come with great caveats:

    The boy, first treated in February at just 7 months old, still needs a special diet and medication; the experimental therapy alone isn’t enough to prevent a dangerous buildup of ammonia in his blood caused by a faulty gene for a key liver enzyme. Still, the swift development of a gene editor that appears to have repaired the defect in some of his liver cells is a landmark demonstration of a personalized approach that has tantalized rare disease researchers.

    Meanwhile, even renowned institutions starting from best intentions, get it horribly wrong, because the interactions are just that hard to model (e.g. [emphasis mine] https://www.science.org/content/article/exclusive-death-girl-chinese-gene-editing-trial-was-never-made-public):

    That vague language glossed over tragedy: Seven days after the girl’s medical team infused trillions of viruses carrying the recipe for the base editor into her spinal fluid, she died of a severe immune reaction linked to the therapy, Science and Retraction Watch can now reveal.

    In a possible future, itself perhaps locked in to some other timeline, your dreams may be possible for your grandchildren and great-grandchildren. But today, they’re just as likely to get you dead.


  • Can’t we identify the genes responsible for their stomach formation

    Absolutely.

    and CRISPR them unto humans, theoretically giving them the same abilities?

    Absolutely not.

    CRISPR and related techniques are not magic. The interplay between gene presence and trait expression is absurdly more complicated than that. You cannot simply “edit in” entire biological adaptations, that’s not how it works.

    The most likely scenario in such an attempt would simply be nothing. Other possibilities include: Autoimmune lifelong digestive system issues, and death, amongst many others.


  • Promethiel@lemmy.worldtoScience Memes@mander.xyzjerks
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    3 months ago

    It literally is a box full of mosquitoes lol.

    Researchers do stick their hands in, and they absolutely breathe because the enclosures can be used to selectively control the air exchange and you sometimes need to elicit a response.

    You’re correct that mosquitoes find us in big part by detecting the co2 we expel during respiration.

    The bastards, the only way to avoid them is when you stop breathing.